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John F. Enders Research Laboratories I graduated from the University of Ankara in June 1992. The following year, the Turkish government awarded me a scholarship for graduate study abroad. After earning my PhD in 2002 from the Department of Biochemistry and Molecular Genetics at the University of Virginia, I joined the Freeman lab as a postdoctoral fellow. Here, I have applied my experience and skills in androgen action to the problem of how androgen and growth factor signaling pathways intersect in prostate cancer. My principal focus is on uncovering signal transduction mechanisms that promote the transition to metastatic disease in prostate cancer. I was trained as a biochemist and cancer biologist during my PhD studies, when I focused on (i) androgen/AR regulation of prostate cancer cell growth and (ii) regulation of the PSA promoter by NF-kappa B in several prostate cancer models. This training helped establish my current interests in cellular signaling. Currently, my research aims to understand the intersection of cell signaling through the AR and the PI3-kinase-Akt signaling pathways. I believe that understanding these signaling pathways will provide new insight into mechanisms underlying the transition to the androgen-independent state and thus help in the development of new therapeutic approaches to the clinical disease. My hobbies are playing volleyball, watching basketball and football games, and reading books. Selected Research Articles Ye, Q., Chung, L.W.K., Cinar, B., Li, S., and Zhau, H.E. (2000) Identification and characterization of estrogen receptor variants in prostate cancer cell lines. J. Steroid Biochem. Mol. Biol. 75(1): 21-31. Ye, Q., Cinar, B., Edlund, M., Chung, L.W.K., and Zhau, H.E. (2001) Inhibition of growth and cell cycle arrest of ARCaP human prostate cancer cells by ectopic expression of ER-alpha. Mol. Cell. Biochem. 228:105-10. Cinar, B., Koeneman, K.S., Edlund, M., Prins, G.S., Zhau, H.E., and Chung, L.W.K. (2001) Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line. Cancer Res. 61:7310-7317. Davis, R., Dingwu, J.I.A., Cinar, B., Sikka, S.C., Moparty, K., Zhau, H.E., Chung, L.W.K., Agrawal, K.C., and Abdel-Mageed, A.B. (2003) Functional androgen receptor confers sensitization of androgen independent prostate cancer cells to anticancer therapy. Biochem. Biophys. Res. Comm. 309:937-945. Cinar, B., Yeung, F., Mayo, M.W., Freeman, M.R., Zhau, H.Y.E., and Chung, L.W.K. (2004) Identification of a negative regulatory cis-element in the enhancer core region of the prostate specific antigen (PSA) promoter: Implications for intersection of androgen receptor and nuclear factor-B signaling in prostate cancer cells. Biochem. J. 379:421-431. Cinar, B., de Benedetti, A., and Freeman, M.R. (2005) Post-translational regulation of the androgen receptor by the mammalian target of rapamycin. Cancer Res. 65:2547-53. Freeman, M.R., Cinar, B., and Lu, M.L. (2005) Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrin. Metabol. 16:273-79. Mukhopadhyay, N.K., Ferdinand, A.S., Cinar, B., Mukhopadhyay, L., Richie, J.P., and Liu, B.C. (2006) Unraveling androgen receptor interactions by an array-based method and discovery of proto-oncogene c-Rel as a negative regulator of androgen receptor. Exp. Cell Res. 312:3782-95. Freeman, M.R, Cinar, B., Kim, K., Mukhopadhyay, R.N, Di Vizio, D., Adam, R.M, and Solomon, K.R. (2007) Transit of Hormonal and EGF receptor-dependent Signals Through Cholesterol-rich Membranes. Steroids, 72:210-217. Adam, R.M., Mukhopadhyay, N.K., Kim, J., Di Vizio, D., Cinar, B., Solomon, K.R., and Freeman, MR. (2007) Cholesterol-sensitivity of endogenous and myristoylated Akt in prostate cancer cells. Cancer Res., 67: 6238-46. Mukhopadhyay, N.K., Cinar, B., Mukhopadhyay, L., Lutchman, M.,
Ferdinand, A.S., Chung, L.W.K., Adam, R.M., Ray, S.K., Leiter,
A.B., Richie, J.P., Liu, B. C.-S., and Freeman, M.R. (2007) The
zinc finger protein RREB-1 is a co-regulator of the androgen receptor:
Implications for the role of the Ras pathway in enhancing androgenic
signaling in prostate cancer. Molecular Endocrinology June 5 [Epub
ahead of print]. Cinar, B., Mukhopadhyay, N.K., Meng, G., and Freeman, M.R. (2007) Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. Journal of Biological Chemistry [Epub ahead of print]. |
Bekir
Cinar, Ph.D.Copyright
© 2003 Michael R. Freeman. All Rights Reserved.
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