Paul D. Guthrie, B.A.
Leading Technician

John F. Enders Research Laboratories
Room 1150
300 Longwood Avenue
Boston, MA 02115
617-919-2638 (office)
617-730-0238 (fax)
paul.guthrie@childrens.harvard.edu

Born and raised in San Angelo, Texas, I graduated from the University of Texas at Austin in 1968, with a Bachelor of Arts in Microbiology. Between 1968 and 1990, I was variously a research technician and research associate in the Department of Virology at Baylor College of Medicine, the Department of Physiology at the University of Texas Medical School at Houston, and the Department of Urology at UT-M.D. Anderson Cancer Center, all in the Texas Medical Center (Houston). I was involved in some pioneering work on characterization of the RNA contained in murine sarcoma/leukemia virus (source of reverse transcriptase; you couldn’t buy it for any amount of money back then) and the bioactive gastrointestinal peptides (gastrin, EGF, secretin, cholecystokinin).

I came to Boston with Michael Freeman in 1990 to start up the research lab for the Department (Division back then) of Urology at Children’s. Since then, my interests and projects have been wide and varied, from basic molecular biology (techniques that would have been indistinguishable from magic in 1968) to current forays into proteomics and mass spectrometry.

At home in Maynard, my wife Sylvia (a grantwriter and development director at Massachusetts Audubon Society) and I devote our spare time to raising two cats and maintaining the best-looking flower garden outside of Route 128. My own passions include computer graphics, science fiction, and astronomy (a hobby since 1960).

Over the past 13 years, we’ve seen a lot of good people (MDs, PhDs, and summer students) come through the lab. At least three of our tender undergraduates have gone on to med school at fine institutions like Washington University in St. Louis and are now contributing somewhere out there in the medical community. We’ve received untiring support from Dr. Retik and the Department; if you’ve got to live and work outside of Texas, this is the place to be. Hook ‘em, Horns! Texas Number One!