Marsha A. Moses, Ph.D.
Professor

Department of Surgery, Harvard Medical School
Vascular Biology Program, Children's Hospital
Karp Family Research Laboratories, Rm 12.214
300 Longwood Avenue
Boston, MA 02115

ph: (617) 919-2207
fax: (617) 730-0231
marsha.moses@childrens.harvard.edu

Dr. Moses is an Associate Professor of Surgery at Harvard Medical School and a Principal Investigator and Staff Scientist in the Vascular Biology Program at Children’s Hospital Boston. She is an internationally recognized expert in the regulation of angiogenesis. A biochemist by training, Dr. Moses leads a research group that conducts both basic and translational research. She and her group have discovered five different angiogenesis inhibitors, three as the lead group and two as the collaborating group. Of these, three inhibitors are currently in clinical development for use against a variety of cancers. In addition, as an outgrowth of an ongoing proteomics program in the laboratory, she has developed a non-invasive urine test for cancer that is based on the detection of a family of enzymes called the matrix metalloproteinases, a group of proteins associated with the metastatic phenotype that the Moses Lab first showed were required for successful angiogenesis. This urine test is currently in clinical development as well.

Currently, a major initiative in the Moses Lab is the identification and characterization of the genes and proteins responsible for the “angiogenic switch”, i.e., the stage during tumor progression in which a small benign tumor becomes angiogenic and eventually malignant. Her group has now identified and verified the genes that are upregulated and those that are downregulated during the angiogenic switch and are developing molecular and biochemical strategies to intervene in ways that prevent this switch.

Dr. Moses has authored over 60 peer-reviewed publications, including articles in Science, Cell, Journal of Cell Biology, and Journal of Biological Chemistry, and she has presented over 85 lectures to national and international audiences.

Among the various awards and honors that Dr. Moses has received are the Cancer Research Foundation Award, the American Cancer Society Research Award, the CaPCURE Research Award, the Center for Excellence in Women’s Health Research Award at Harvard Medical School, and the Clifford A. Barger Excellence in Mentoring Award of Harvard Medical School. She also serves on a number of peer review committees for the NIH, the American Cancer Society (ACS), and other funding agencies, and is currently the Chair of the Cell Structure and Metastasis Peer Review Committee of the ACS.

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