Keith Solomon, Ph.D.
Collaborator
Staff Scientist, Orthopedic Surgery
Children’s Hospital Boston
Assistant Professor, Orthopedic Surgery
Harvard Medical School

John F. Enders Research Laboratories
Room 1230
300 Longwood Avenue
Boston, MA 02115
617-355-4055(office)
617-730-0239
keith.solomon@childrens.harvard.edu

Keith R. Solomon, Ph.D. is an Assistant Professor in Orthopedic Surgery at Harvard Medical School and a Staff Scientist in Orthopedic Surgery at Children’s Hospital Boston. He received his Ph.D. in Immunology from Harvard University in 1996. Dr. Solomon has been studying lipid raft membrane microdomains for the last 10 years and has been involved in pioneering research regarding the function and organization of lipid rafts in lymphocytes, macrophages, osteoblasts, pericytes, and smooth muscle cells. Dr. Solomon has been collaborating with the Freeman lab for the last 3 years in investigating the role that cholesterol and lipid rafts play in the ability of prostate cancer (PCa) cells to resist pro-apoptotic signals in vitro and in the growth of prostatic tumors in vivo.

Selected Publications

Solomon, K.R., Rudd, C., and Finberg, R.W. The association between GPI-anchored proteins and heterotrimeric G protein a subunits in lymphocytes. Proc. Natl. Acad. Sci. 1996. 93:6053-6058.

Solomon, K.R., Mallory, M., and Finberg, R.W. Determination of the non-ionic detergent insolubility and phosphoprotein associations of GPI-anchored proteins expressed on T cells. 1998. Biochemical Journal. 1998, 334:325-333.

Solomon, K.R., Kurt-Jones, E.A., Saladino, R.A., Stack, A.M., Dunn, I.F., and Finberg, R.W. Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide. J. Clin. Invest. 1998, 102:2019-2027.

Solomon, K.R., Danciu, T.E., Adolphson, L.D., Hecht, L.E., and Hauschka P.V. Caveolin-enriched membrane signaling complexes in human and murine osteoblasts. J. Bone Min. Res. 2000, 15:2380-2390.

Zhuang, L., Lin, J., Lu, M. L., Solomon, K. R., and Freeman, M. R. Cholesterol-Rich Lipid Rafts Regulate Growth Factor-Activated Akt Signaling and Cell Survival in Human Prostate Cancer Cell. Cancer Res. 2002, 62:2227-2231.

Stehr, M., Adam, R.M., Khoury, J., Zhuang, L., Solomon, K.R., Peters, C.A., and Freeman, M.R. (2003) Platelet-derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signaling. Journal of Urology 169:1165-1170.

Kim, J., Adam, R.M., Solomon, K.R. and Freeman, M.R. (2004) Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Endocrinol. 145(2):613-619.

Freeman, M.R. and Solomon, K.R. (2004) Cholesterol and prostate cancer. J. Cell. Biochem. 91:54-69.

Stehr, M., Estrada, C., Khoury, J., Danciu, T., Sullivan, M.P., Peters, C.A., Solomon, K.R., Freeman, M.R., and Adam, R.M. (2004) Caveolae are negative regulators of TGF1 signaling in ureteral smooth muscle cells. Journal of Urology 172:2451-2455.

Solomon, K.R., Sharma, P., Chan, M., Morrison, P.T., and Finberg, R.W. (2004) CD109 represents a novel branch of the α2-macroglobulin /complement gene family. Gene 327:171-183.

Zhuang, L., Kim, J., Adam, R.M., Solomon, K.R., and Freeman, M.R. (2005) Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest.115(4):959-68.

MacLellan, D.L., Steen, H., Adam, R.M., Garlick, M., Zurakowski, D., Gygi, S.P., Freeman, M.R., and Solomon, K.R. (2005) A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells. Proteomics.5(18):4733-42.

Boucher, K., Siegel, C.S., Sharma, P., Hauschka, P.V., and Solomon, K.R. (2006) HMG-CoA reductase inhibitors induce apoptosis in pericytes. Microvasc Res. 71:91-102

Lutchman, M., Solomon, K.R., and Freeman, M.R. (2006) Cholesterol, Cell Signaling and Prostate Cancer in Prostate Cancer: Novel Biology, Genetics and Therapy. (Eds. Chung, Isaacs, and Simons). The Humana Press Inc. (In Press).

Hager, M.H., Solomon, K.R., and Freeman, M.R. (2006) The role of cholesterol in prostate cancer. Curr Opin Clin Nutr Metab Care. 9:379-385.

Freeman, M.R., Solomon, K.R., and Moyad, M. (2006) Statins and the risk of cancer. JAMA. 295:2720-1[letter]

Fang, P-K, Solomon, K.R., Zhuang, L., Qi, L., McKee, M, Freeman, M.R, and Yelick, P.C. (2006) Caveolin-1α and -1β perform non-redundant roles in early vertebrate development.  Amer. J. Path. 169:2209-2222.

Sharma, P., Solomon, K.R., and Hauschka, P.V. (2006) High-Throughput Tool for Discovery of Bone Regulating Factors. Biotechniques. 41:539-542.

Freeman, M.R., Cinar, B., Kim, J., Mukhopadhyay, N., Di Vizio, D., Adam ,R.M., and Solomon, K.R. (2006) Transit of Hormonal and EGF receptor-dependent Signals Through Cholesterol-rich Membranes. Steroids; 72:210-7.

Sundberg, C., Friman, T., Hecht, L. E.. Kuhl, C., and Solomon, K.R.  (2007)  PDGF-BB producing cells dictate biological endpoints in receptor bearing cells through targeting specific cohorts of PDGF beta-receptors.  (Submitted AJPath). 

Adam, R.M., Mukhopadhyay, N.K., Kim, J., DiVizio, D., Cinar, B., Boucher, K., Solomon, K.R., and Freeman, M.R.  (2007) Cholesterol-sensitive Signaling from Akt (In press Cancer Research).

Solomon, K.R. and Freeman, M.R. (2007) Statin Drugs in Prostate Cancer Prevention or Treatment: How to Ask the Right Question.  (In press Trends Endo. Met).

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