Our laboratory studies the molecular basis of diseases of the genitourinary tract, including prostate and bladder cancer, congenital diseases of the urinary system, and bladder dysfunction associated with aging and with developmental abnormalities. We use a range of molecular tools and model systems, including molecular biology and biochemistry approaches, cell culture systems, proteomics technologies, and animal models, including the mouse, rat, and the zebrafish.

• Cancer biology
• Smooth muscle cell growth and tissue remodeling
• Cell survival signal transduction
• EGF-like growth factors

Reprinted from The American Journal of Pathology, Volume 169, Issue 6 (December 2006) with permission from the American Society for Investigative Pathology.

Cholesterol plays a role in the regulation of cell signaling mechanisms in cancer. more

Michael R. Freeman, Ph.D.
John F. Enders Research Laboratories
Suite 1161
300 Longwood Avenue
Boston, MA 02115
617-919-2644 (office)
617-730-0238 (fax)
Michael.Freeman@childrens.harvard.edu

Front row (l to r): Dolores Di Vizio, Amy Nichols, Jayoung Kim
Back row: (l to r): Nishit Mukhopadhyay, Jordan Dimitrakov, Martin Hager, Jaeseop Lee, Wei Yang, Michael Freeman, Erica Thompson, Raj Jhaveri, Andrew Briscoe, Paul Guthrie, Bekir Cinar